indigo carmine toxicity
A discolouration of urine may be observed following administration of indigotin (indigo carmine). 2013 Feb;121(2 Pt 2 Suppl 1):449-51. doi: 10.1097/aog.0b013e31826d21ec. Indigo carmine is largely bound to protein plasma. 5 mL ampoules in type I brown glass. In case of overdose, a peripheral vasodilator therapy may be considered. Long-term oral studies in rats and mice generated no clear indication of any carcinogenic potential. A case of occupational asthma has also been reported. An overdose could induce a hypertensive crisis and severe bradycardia. USA.gov. IC is traditionally used as pH indicator or food colorant. However, long-term studies in rats (oral) and mice (subcutaneous) have not revealed any carcinogenic effects. 2015 Aug;187(8):530. doi: 10.1007/s10661-015-4742-9. The biological half-life is 4 to 5 minutes following intravenous injection. The efficacy and safety of Indigo carmine in children has not been established (see section 4.4). Environ Sci Pollut Res Int. The Indigo carmine (IC) dye has been widely used in textile industries, even though it has been considered toxic for rats, pigs and humans. Elimination of the dye begins soon after injection, appearing in the urine within 10 minutes in average cases. Hypersensitivity to the active substance or to dyes. Copyright (c) 2014 Bibra toxicology advice & consulting Ltd. All rights reserved. • coronary disorders due to its peripheral vasoconstrictor effect. However oral availability is approximately 3%. To this end, lethal (mortality) and sub-lethal (loss or gain of biomass, reproduction, behavior, morphological changes and immune system cells) effects caused by this substance and its degradation products in these annelids were evaluated. NLM It is therefore necessary to monitor heart rate and blood pressure during and a few minutes after the injection. Bioindicator; Dye; Earthworm; Immunotoxicity; Photodegradation. The Indigo carmine (IC) dye has been widely used in textile industries, even though it has been considered toxic for rats, pigs and humans. The Panel agreed with the authors that the NOAEL identified in this study was 5 % in the diet providing an average intake of 8259 mg Indigo Carmine/kg bw/day for males and 9456 mg Indigo Carmine/kg bw/day for females. A decision must be made whether to discontinue breast-feeding or to abstain from indigotin (indigo carmine) administration taking into account the benefit of breastfeeding for the child and the benefit of therapy for the woman. There is no data in patients with liver impairement, however no dosage adjustment is necessary. Dabei wird seine Umwandlung in Isatin-5-Sulfonsäure genutzt, die jedoch auch mit Hyperoxiden eintritt. 2018 Jan;147:1-8. doi: 10.1016/j.ecoenv.2017.08.018. Acute toxicity data for indigotin (indigo carmine) are available from rat and mouse studies. Ecotoxicol Environ Saf. A negative influence of the dye on the reproduction rate was observed, while by-products affected juvenile survival. McShane H, Sarrazin M, Whalen JK, Hendershot WH, Sunahara GI. This information is intended for use by health professionals, Indigo carmine 40 mg/5 mL solution for injection, Indigotin (indigo carmine) ……………………………………………………………………………….……….40 mg. For the full list of excipients, see section 6.1. Environ Toxicol Chem. Get the latest public health information from CDC: https://www.coronavirus.gov. Indigo carmine is possibly a weak local sensitizer. Intravenous injection should be stopped if the following symptoms occur: bradycardia, tachycardia, hypotension, hypertension, rash or erythema, respiratory symptoms such as dyspnea or bronchospasm. Precautions to be taken before administering the medicinal product. Indigotin (indigo carmine) may interfere with pulse oxymetric methods. Acute toxicity data for indigotin (indigo carmine) are available from rat and mouse studies. Qualitative and quantitative composition, 4.2 Posology and method of administration, 4.4 Special warnings and precautions for use, 4.5 Interaction with other medicinal products and other forms of interaction, 4.7 Effects on ability to drive and use machines, 6.6 Special precautions for disposal and other handling, 9.
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